Cancer surgery with drags — progress in China.

Cancer surgery with drags — progress in China
Academician Oleg Figovsky

Key recent headlines in cancer immunotherapy include major developments in lung, bladder, breast, colorectal, and ovarian cancers, including strong early-phase data and important regulatory updates. On March 12, the first mature overall survival (OS) data from the phase 3 LIBRETTO-001 study were published in JCO and showed substantial long-term benefits with selpercatinib, a RET kinase inhibitor, in patients with RET fusion–positive non-small cell lung cancer (NSCLC). Pretreated patients had a 62% objective response rate (ORR) compared with 83% among treatment-naïve patients. The median progression-free survival (PFS) was 26.2 months and 22.0 months, respectively, with a median follow-up of 40 months. Notably, after a median follow-up of 43 months, the median OS was 47.6 months among those pretreated and was not reached in those who were treatment-naïve. Below are given a few latest Chinese patents on the field of the cancer surgery with drags.

CN221308261 (U) — Armpit muscle fascia spreading and fixing device for double-layer same-direction breast cancer surgery

The armpit muscle fascia spreading fixing device for the double-layer same-direction breast cancer surgery comprises a square plate and an electric telescopic rod, a fascia spreading fixing structure is arranged at one end of the electric telescopic rod and comprises a first shell, a motor is fixedly connected to the inner wall of the first shell through a support, and the motor is fixedly connected with the electric telescopic rod. The vertical rod penetrates through the limiting plate and the first shell and is connected with the limiting plate and the first shell in a sleeving mode, the two ends of the limiting plate are fixedly connected with the two sides of the inner wall of the first shell correspondingly, and the motor is started to drive the double-end stud to rotate in the first shell through cooperation of the fascia pushing-open fixing structure and the drag hook head; and meanwhile, a vertical rod is driven to move upwards in a limiting plate and a first shell, a plurality of drag hook heads are driven to move upwards, a first layer of fascia is pushed open and fixed upwards, then an external power source of a motor on the lower side is connected, a second layer of fascia is pushed open and fixed, the fascia can be pushed open in a layered mode, and the working limitation of equipment is reduced.

CN220193076 (U) — Skin retractor device for breast cancer surgery

The utility model relates to a skin drag hook device for breast cancer surgery, which comprises a vertical support, a transverse support and drag hooks, the vertical support is used for being fixed on a surgical bed, the transverse support is fixed at the upper end of the vertical support, the vertical support is provided with a plurality of drag hooks, and the drag hooks are fixed on the transverse support. The device is characterized in that a groove is formed in the lower surface of the transverse support in the length direction, the drag hook comprises a sliding block, a tying rope and a skin clamp, the sliding block is installed in the groove in a sliding mode, a button nail used for locking the sliding block in the groove is installed on the sliding block, the upper end of the tying rope is connected with the sliding block, and the lower end of the tying rope is connected with the skin clamp. The structure of the transverse support and the structure of the drag hook assembly are ingeniously designed, so that the drag hook assembly can conveniently, rapidly and flexibly move on the transverse support and can be fixed at any time, adjustment can be conducted according to the size and the position of a surgical incision, lesion tissue is fully and completely exposed, and surgical operation of a doctor is facilitated.

CN220109775 (U) — Retractor for breast cancer operation

The utility model discloses a breast cancer operation drag hook which comprises a handheld piece, a sliding rail and two sliding blocks, the handheld piece is fixedly arranged on the sliding rail, drag hook rods are arranged on the sliding blocks, the drag hook rods are spherically hinged to the sliding blocks, and the handheld piece and the drag hook rods are oppositely arranged on the two sides of the sliding rail. The sliding block can drive the drag hook rods to move on the sliding rail, the two drag hook rods can freely move on the sliding rail to the width suitable for the notch, the drag hook rods are spherically hinged to the sliding block, the drag hook rods can rotate around the axis of a spherical hinge support on the sliding block, and the drag hook rods can be rotated to the proper angle according to needs to be matched with the notch to form tension. The handheld part is arranged on the sliding rail, a user can conveniently grasp the breast cancer operation drag hook, the two drag hook rods are arranged on the sliding rail, the user can use the breast cancer operation drag hook with one hand to provide tension, the other hand can assist a surgeon in other work, and the working efficiency is improved. The breast cancer surgery retractor has the advantages of being convenient to grasp, adjustable, high in working efficiency and the like.

CN219147715 (U) — Drag hook for gynecological laparoscopic surgery

The utility model discloses a retractor for gynecologic laparoscopic surgery, which relates to the field of gynecologic laparoscopic surgery and comprises a mounting cylinder and a control handle, the control handle is slidably mounted in an inner cavity of the mounting cylinder, one end of the control handle is fixedly connected with an elastic plate, the inner wall of the elastic plate is fixedly connected with an elastic barrier film, and an inner cavity of the control handle is fixedly connected with a guide plate. The guide plate is obliquely arranged, the outer wall of one side of the guide plate is in an arc shape, the outer wall of the side, away from the elastic barrier film, of the elastic plate is arranged to be a smooth arc-shaped curved surface, a guide block is fixedly connected to the inner wall of the mounting cylinder, a guide cavity is formed in the outer wall of the control handle, and the end, away from the mounting cylinder, of the guide block extends to an inner cavity of the guide cavity. And the mounting cylinder is slidably attached to the inner wall of the guide cavity, and the outer wall of the mounting cylinder is fixedly connected with a handheld ring. By means of the structural matching, the gynecological ovarian cancer operation support can support the intestinal tract and shield the rectum, the colon and the momentum majus in gynecological ovarian cancer or other gynecological tumor operations, and can effectively prevent gynecological tumor tissue from being planted.

CN218960812 (U) — Novel skin flap extension drag hook for breast cancer operation

The utility model relates to the technical field of medical instruments, in particular to a novel skin flap extension draw hook for breast cancer surgery, which comprises two draw hooks and a pair of operating forceps, the draw hooks are arranged on the operating forceps, the operating forceps comprise a first forceps body, a second forceps body and a rotating component, and the rotating component comprises a fluted disc, a rotating disc and a connecting piece. The first plier body is composed of a first fixing rod and a first pull rod, the first fixing rod and the first pull rod are fixed to the rotary disc, the second plier body is composed of a second fixing rod and a second pull rod, the second fixing rod and the second pull rod are fixed to the fluted disc, and the fluted disc is rotationally connected with the rotary disc through a connecting piece. The two drag hooks are fixed to the end of the first pull rod and the end of the second pull rod respectively, through cooperative use of the operating forceps and the rotating assembly, it can be guaranteed that the first forceps body and the second forceps body are kept in a stable state after being unfolded, the skin flap unfolding effect of the drag hooks is good, the unfolding range of the two drag hooks can be effectively expanded, and the skin flap unfolding efficiency is improved. The operation on the tissue at the skin flap is facilitated.

CN215874749 (U) — Drag hook for breast cancer operation

The utility model discloses a retractor for breast cancer surgery, and belongs to the technical field of breast cancer surgical instruments. The drag hook comprises two supporting rods, the two supporting rods are symmetrically arranged on the two sides of the bed body, and each supporting rod is provided with a fixing piece at the same height. The number of the drag hooks is two, the drag hooks are arranged on the fixing pieces through connecting components in the horizontal direction, the connecting components comprise first length-adjustable connecting pieces arranged on the fixing pieces in the horizontal direction, one ends of first connecting rods are hinged to the fixing pieces, and the other ends of the first connecting rods are fixedly connected with the drag hooks. And the second length-adjustable connecting piece is obliquely arranged between the first connecting rod and the fixing piece, and the end parts of the second length-adjustable connecting piece are respectively hinged to the first connecting rod and the fixing piece. The triangular stable structure is formed by the first connecting piece and the second connecting piece, the first connecting piece and the second connecting piece are hinged to the fixing piece respectively, the angle of the drag hook can be adjusted according to the cutting direction of a knife edge, and the universal applicability is achieved.

CN215273008 (U) — Mammary gland flap separation drag hook

The utility model discloses a breast flap separation drag hook which comprises a U-shaped support, drag hooks are fixedly connected to the two ends of the U-shaped support respectively, and a smoke suction pipeline is fixedly connected to the middle of the U-shaped support. One end of the head part is provided with a smoke collecting part, the smoke collecting part is communicated with a smoke sucking pipeline, and the smoke collecting part smoothly bends and extends along the bending direction of the drag hook and is lower than the lowest point of the claw of the drag hook; the breast cancer surgery retractor is structurally provided with the two retractor heads, so that a surgery assistant can expose enough visual field by pulling with one hand, the other hand of the surgery assistant can perform other surgery operations, the number of breast cancer surgery assistants is reduced, and the labor intensity of doctors is reduced; the retractor is provided with the smoke suction pipeline, and the retractor is connected with the aspirator through the smoke suction pipeline, so that smoke generated in an operation can be continuously sucked while the skin flap is lifted, the injury of the operation smoke to medical care is effectively reduced, and the practicability of the retractor is improved.

CN213156114 (U) — Skin drag hook special for breast cancer surgery

The utility model relates to the technical field of breast cancer surgical instruments, in particular to a special skin retractor for breast cancer surgery, which overcomes the defect that the skin of a patient needs to be supported by cooperation of multiple persons in the existing breast cancer surgery process, and comprises a lifting frame, a horizontal cross shaft is welded on the inner side of the bottom of the lifting frame, and a sleeve rod is erected through the cross shaft. An elastic ring is connected to the outer side of the end of the sleeve rod, four spring pieces are further welded to the end of the sleeve rod, a telescopic rod is inserted into the sleeve rod in a penetrating mode, the end of the telescopic rod is connected with a drag hook clamp through a rotating shaft, a bearing is clamped to the outer side of the lower portion of the elastic ring, and the elastic ring can be rotated to drive the sleeve ring connected with the bearing at the bottom of the elastic ring to achieve lifting operation. When the sleeve ring descends through the limiting block arranged on the inner wall, the spring piece at the end of the sleeve rod is extruded, the spring piece clamps and fixes the telescopic rod arranged in the sleeve rod through the silica gel pad adhered to one side, the length of the telescopic rod is conveniently adjusted, and the skin retractor requirement is met.

CN211862872 (U) — Drag hook for thoracic surgery

The utility model discloses a draw hook for thoracic surgery, which relates to the field of medical instruments and mainly comprises a bed frame, a sliding rod is arranged on the bed frame, one end of the sliding rod is fixed on a sliding rod frame, a sliding sleeve is arranged at one end of the sliding rod far away from the sliding rod frame, and a short hook and a long hook are hung on the sliding sleeve at a certain interval; the hand wheel shaft is rotated to drive the lead screw to move upwards, the lead screw jacks the sliding rod frame upwards to enable the sliding rod to tilt upwards,and the drag hooks on the long and short hooks tilt upwards along with the sliding rod and move linearly to open rib gaps to enter the thoracic cavity for an operation. The thoracic cavity retractor has the advantages that different types of retractor bodies can be hung according to operation requirements to adjust the retractor to adapt to the size expansion range of the sternum, the chest wall and the thoracic cavity, and therefore the optimal exposing effect is achieved; medical personnel can accurately adjust and expand the sizes of the sternum, the chest wall and the thoracic cavity by directly operating the instrument without the help of hand strength; the thoracoscope is suitable for total thoracoscope surgical treatment of thoracic diseases such as breast cancer, thyroid cancer, lung cancer and esophageal cancer.

CN209285601 (U) — Flap retractor used in breast surgery

The utility model discloses a flap retractor used in breast surgery. Including a retaining ring, a sponge pad is fixedly arranged at the bottom of the fixing ring; intraoperative treatment of breast cancer, SURGICAL VIEW FOR EXTENDING SURGICAL VIEW, generally, a flap tractor needs to be used; in the prior art, the flap retractor for the breast surgery comprises a fixing ring, four groups of fixing blocks are fixedly arranged on the fixing ring; four steel wires are mounted in the four groups of fixed blocks in a sliding manner; head connecting drag hook of steel wire, when traction is needed, the steel wire is dragged; when the skin flap retractor is used, the crank can be rotated to drive the gear to rotate, and the gear can drive the sliding rod to slide when rotating, so that the skin flap can be shallowly opened by the retractor, and the sliding rod can be conveniently fixed through the arrangement of the clamping jaw.

CN109394399 (A) — Drag sustained release stent

The invention provides a drag sustained release stent. The drag sustained release stent is characterized by comprising a stent body and a polymer membrane, and the stent body and the polymer membrane are connected together; the polymer membrane is a biodegradable polymer membrane or a non-biodegradable polymer membrane, the polymer membrane and/or the stent body is provided with at least one layer of drug coating, and the drug coating includes one or several kinds of antibacterial drugs, anti-inflammatory drugs, anti-cancer drugs and hemostatic drugs. The drug sustained release stent is applied to the treatment of sinusitis, and can not only play a supporting and continuously dosing role in a lesion location after FESS surgery, but also play a role in hemostasis after the surgery.

CN208447671 (U) — Novel flap drag hook for breast surgery

The utility model discloses a novel flap drag hook for breast surgery, including the connecting rod handle, the surface of connecting rod handle is provided with the plastics protective sheath, one side of connecting rod handle is provided with the finger pull ring, one side of finger pull ring is provided with active tube and light guide tube, active tube’s inside is provided with the bottom plate, one side of bottom plate is provided with the flap pull rod, one side of flap pull rod is provided with the flap drag hook, the bottom of flap pull rod is provided with the fixed column, the bottom of fixed column is provided with turns round tight connecting rod, light guide tube’s inside is provided with the battery, the top of battery is provided with the head that charges, one side of battery is provided with emitting diode, one side of emitting diode is provided with the condensing lens, one side of condensing lens is provided with light source sensor, save time and the cost when the free flap of breast cancer radical operation is realized being expert at by the instrument, just can accomplish efficiently alone, can anti-skiddingly move with the hand power of being convenient for the length of can freely stretch out and draw back simultaneously, the suitability of improvement instrument, two its effects of drag hooks improvement.

CN101366645 (A) — Multifunctional drag hook for mammary cancer surgery

The invention discloses a brand-new multi-functional draw hook for use in breast cancer operation. The draw hook comprises a left grab hook and a right grab hook, a left nut seat and a right nut seat, clockwise and counterclockwise threaded screw rods, an adjusting wheel disk, and a hauling rope which are arranged in an operating handle box and so on. The draw hook is mainly characterized in that the adjusting wheel disk and the clockwise and counterclockwise threaded screw rods are integrated into a whole; when the adjusting wheel disk is turned, the draw hook can be adjusted into a single draw hook, can also be adjusted into double draw hooks at various intervals (intervals between claw-ends),thereby meeting the exposure requirement of various concrete positions conveniently, flexibly and reliably, and not requiring drawing by hands for a long time. The draw hook can ensure that an operator conveniently performs the operation, particularly can help to completely sweep axillary glands to achieve the technical requirements of the breast cancer operation, is convenient for the operation, increases the efficiency, and improves the prognosis.

CN202821463 (U) — Thoracoscopic surgery tractive device

The utility model discloses a thoracoscopic surgery tractive device which comprises a tractive device body. The tractive device body is in an L shape and is formed by a handheld segment, a transition segment and an inserting segment, wherein connection parts of the handheld segment, the transition segment and the inserting segment are in an arc shape and play roles of transition connection. The whole of the inserting segment is in a long-strip shape. The inner surface of the inserting segment dents inwards. The end portion of the inserting segment is bent towards the direction of the handheld segment. A hanging hole which provides convenience for hanging and installation of the tractive device body is formed in the handheld segment. The thoracoscopic surgery tractive device has the advantages of being simple in structure and operation, convenient to operate, good in safety and surgery exposure property, effective in overcoming the defects of an existing surgery drag hook which are generally used in thoracoscopic surgeries, and applicable to full thoracoscopic surgery treatment of chest diseases such as lung cancer, esophagus cancer, cardia cancer and mediastinal tumor.

Researchers in China have used the body’s own immune system to kill cancerous cells in a pioneering new therapy. In a trailblazing fusion of immunology and ingenuity, a team of Chinese researchers have been engineering tumors to mimic pork, thereby triggering the body’s immune system to attack them with unprecedented precision. Their pioneering study, published in the journal Cell on January 18, 2025 uses a genetically modified virus to “disguise” cancer cells as foreign pig tissue, sparking a hyperacute immune rejection response that attacks the tumours while leaving healthy cells untouched.

Early clinical trials report staggering success: 90 per cent of patients with advanced, treatment-resistant cancers – such as liver, ovarian and lung – achieved halted tumour growth or shrinkage, with one cervical cancer patient declared clinically cured. By repurposing a mechanism that is notorious for organ transplant rejection, this “tumour-to-pork” strategy has opened a new frontier in the fight against cancer, offering hope where conventional therapies have failed.

Big Pharma companies have rushed to get their own drugs to compete with Summit’s product. There was one deal in November, when Merck licensed an experimental drug from a Chinese drug maker for around $500 million up front and another $2.7 billion in potential milestone payments. The biggest deals have come in just the past two weeks. In mid of May, Pfizer said it would pay the Chinese biotech 3SBio $1.3 billion up front for its own competitor to the Summit drug, plus billions more in potential milestone payments. Pfizer is also making a $100 million equity investment in 3SBio.

Иллюстрация: yangva.ru